Biomarkers /

PIGA

Back to Biomarkers List

Overview

Location [1]
Xp22.2
Protein [2]
Phosphatidylinositol N-acetylglucosaminyltransferase subunit A
Synonyms [1]
GPI3, PIG-A, MCAHS2, PNH1

PIGA is altered in 0.24% of all cancers with colon adenocarcinoma, unknown, acute myeloid leukemia, anaplastic large cell lymphoma, and B-cell lymphoblastic leukemia/lymphoma having the greatest prevalence of alterations [3].

PIGA GENIE Cases - Top Diseases

The most common alterations in PIGA are PIGA Amplification (0.07%), PIGA C36Y (0.05%), PIGA Loss (0.05%), PIGA T123M (0.17%), and PIGA A133G (0.02%) [3].

PIGA GENIE Cases - Top Alterations

References

1. Hart R and Prlic A. Universal Transcript Archive Repository. Version uta_20180821. San Francisco CA: Github;2015. https://github.com/biocommons/uta

2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.

3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

4. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.