Overview

Location [1]
3q26.32
Pathway
PI3K/AKT1/MTOR
Protein [2]
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
Synonyms [1]
CLOVE, CWS5, PI3K, MCAP, PI3K-alpha, MCMTC, p110-alpha, MCM

PIK3CA (phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha) is a gene that encodes the protein phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform, a subunit of the PI3K protein. Phosphatidyl 3-kinases (PI3K) are a family of lipid kinases involved in many cellular processes, including cell growth, proliferation, differentiation, motility, and survival. Mutant PIK3CA has been implicated in the pathogenesis of several cancers, including colon cancer, glioma, gastric cancer, breast cancer, endometrial cancer, and lung cancer (COSMIC; PMID: 15016963).

 

PIK3CA is altered in 13.92% of all cancers with breast carcinoma, colorectal adenocarcinoma, uterine corpus neoplasm, non-small cell lung carcinoma, and malignant glioma having the greatest prevalence of alterations [3].

PIK3CA GENIE Cases - Top Diseases

The most common alterations in PIK3CA are PIK3CA Mutation (18.16%), PIK3CA Mutation (somatic) (18.16%), PIK3CA H1047R (4.31%), PIK3CA E545K (3.74%), and PIK3CA E542K (2.33%) [3].

PIK3CA GENIE Cases - Top Alterations

Biomarker-Directed Therapies

Significance of PIK3CA in Diseases

Breast Carcinoma +

Malignant Solid Tumor +

Non-Small Cell Lung Carcinoma +

Colorectal Carcinoma +

Endometrial Carcinoma +

Head And Neck Squamous Cell Carcinoma +

Squamous Cell Lung Carcinoma +

Cancer +

Melanoma +

Non-Hodgkin Lymphoma +

Ovarian Carcinoma +

Glioblastoma +

Gastric Adenocarcinoma +

Pancreatic Carcinoma +

Lymphoma +

Multiple Myeloma +

Bladder Carcinoma +

Colon Adenocarcinoma +

Head And Neck Carcinoma +

Malignant Glioma +

Angiosarcoma +

Anaplastic Astrocytoma +

Adenocarcinoma Of The Gastroesophageal Junction +

Small Cell Lung Carcinoma +

Thyroid Gland Carcinoma +

Undifferentiated Pleomorphic Sarcoma +

Cholangiocarcinoma +

Thymic Carcinoma +

Soft Tissue Sarcoma +

Malignant Peripheral Nerve Sheath Tumor +

Prostate Carcinoma +

Renal Cell Carcinoma +

Sarcoma +

Peritoneal Mesothelioma +

B-Cell Non-Hodgkin Lymphoma +

Hepatocellular Carcinoma +

Leiomyosarcoma +

Extraskeletal Osteosarcoma +

Histiocytic And Dendritic Cell Neoplasm +

Myxofibrosarcoma +

Pleomorphic Liposarcoma +

Pleomorphic Rhabdomyosarcoma +

References

1. Hart R and Prlic A. Universal Transcript Archive Repository. Version uta_20170629. San Francisco CA: Github;2015. https://github.com/biocommons/uta

2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.

3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 4. This dataset does not represent the totality of the genetic landscape; see paper for more information.

4. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.