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PLCG1

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Overview

Location [1]
20q12
Protein [2]
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1
Synonyms [1]
PLC1, PLC148, PLCgamma1, NCKAP3, PLC-II

PLCG1 is altered in 1.13% of all cancers with peripheral T-cell lymphoma, not otherwise specified, high grade ovarian serous adenocarcinoma, diffuse large B-cell lymphoma, not otherwise specified, acute myeloid leukemia, and mantle cell lymphoma having the greatest prevalence of alterations [3].

PLCG1 GENIE Cases - Top Diseases

The most common alterations in PLCG1 are PLCG1 Loss (0.40%), PLCG1 S345F (0.07%), PLCG1 T119M (0.07%), PLCG1 A1278V (0.05%), and PLCG1 E1163K (0.04%) [3].

PLCG1 GENIE Cases - Top Alterations

References

1. Hart R and Prlic A. Universal Transcript Archive Repository. Version uta_20180821. San Francisco CA: Github;2015. https://github.com/biocommons/uta

2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.

3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

4. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.