Biomarkers /

PPP6C

Back to Biomarkers List

Overview

Location [1]
9q33.3
Protein [2]
Serine/threonine-protein phosphatase 6 catalytic subunit, N-terminally processed
Synonyms [1]
PP6, PP6C

PPP6C is altered in 0.67% of all cancers with cutaneous melanoma, breast invasive ductal carcinoma, endometrial endometrioid adenocarcinoma, prostate adenocarcinoma, and colon adenocarcinoma having the greatest prevalence of alterations [3].

PPP6C GENIE Cases - Top Diseases

The most common alterations in PPP6C are PPP6C R264C (0.10%), PPP6C Amplification (0.09%), PPP6C R177* (0.03%), PPP6C E180K (0.02%), and PPP6C Loss (0.02%) [3].

PPP6C GENIE Cases - Top Alterations

References

1. Hart R and Prlic A. Universal Transcript Archive Repository. Version uta_20180821. San Francisco CA: Github;2015. https://github.com/biocommons/uta

2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.

3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

4. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.