Biomarkers /

PRCC

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Associated Diseases

Overview

Location [1]
1q23.1
Protein [2]
Proline-rich protein PRCC
Synonyms [1]
RCCP1, TPRC

PRCC is altered in 0.05% of all cancers with breast invasive ductal carcinoma, translocation-associated renal cell carcinoma, high grade ovarian serous adenocarcinoma, renal cell carcinoma, and uterine corpus carcinosarcoma having the greatest prevalence of alterations [3].

PRCC GENIE Cases - Top Diseases

The most common alterations in PRCC are PRCC-TFE3 Fusion (0.01%), PRCC T72P (1.18%), PRCC M57L (0.53%), PRCC D341N (0.22%), and PRCC I170V (0.39%) [3].

PRCC GENIE Cases - Top Alterations

References

1. Hart R and Prlic A. Universal Transcript Archive Repository. Version uta_20180821. San Francisco CA: Github;2015. https://github.com/biocommons/uta

2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.

3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

4. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.