Overview

Location [1]
6q21
Protein [2]
PR domain zinc finger protein 1
Synonyms [1]
BLIMP1, PRDI-BF1

PR domain containing 1, with ZNF domain (PRDM1) is a gene that encodes a protein that functions as a repressor of beta-interferon gene expression. Fusions, missense mutations, nonsense mutations, silent mutations, whole gene deletions, and frameshift deletions and insertions are observed in cancers such as hematopoietic and lymphoid cancers, intestinal cancer, and skin cancer.

PRDM1 is altered in 1.97% of all cancers with breast invasive ductal carcinoma, colon adenocarcinoma, lung adenocarcinoma, cutaneous melanoma, and melanoma having the greatest prevalence of alterations [3].

PRDM1 GENIE Cases - Top Diseases

The most common alterations in PRDM1 are PRDM1 Mutation (1.31%), PRDM1 Amplification (0.40%), PRDM1 Loss (0.28%), PRDM1 Nonsense (0.05%), and PRDM1 S367F (0.05%) [3].

PRDM1 GENIE Cases - Top Alterations

References

1. Hart R and Prlic A. Universal Transcript Archive Repository. Version uta_20180821. San Francisco CA: Github;2015. https://github.com/biocommons/uta

2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.

3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

4. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.