Location [1]
Protein [2]
Receptor-type tyrosine-protein phosphatase C
Synonyms [1]
CD45R, B220, L-CA, CD45, GP180, T200, LY5, LCA

PTPRC is altered in 2.66% of all cancers with pancreatic adenocarcinoma, cholangiocarcinoma, melanoma, colon adenocarcinoma, and endometrial endometrioid adenocarcinoma having the greatest prevalence of alterations [3].

PTPRC GENIE Cases - Top Diseases

The most common alterations in PTPRC are PTPRC P87L (0.61%), PTPRC A113S (0.26%), PTPRC E624K (0.30%), PTPRC F57L (0.30%), and PTPRC H1292N (0.30%) [3].

PTPRC GENIE Cases - Top Alterations

Significance of PTPRC in Diseases

Non-Small Cell Lung Carcinoma +

Acute Myeloid Leukemia +

Hepatocellular Carcinoma +


1. Hart R and Prlic A. Universal Transcript Archive Repository. Version uta_20180821. San Francisco CA: Github;2015. https://github.com/biocommons/uta

2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.

3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

4. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.