Location [1]
Protein [2]
Receptor-type tyrosine-protein phosphatase delta
Synonyms [1]

Protein tyrosine phosphatase, receptor type, D (PTPRD) is a gene that encodes a protein that functions as a protein tyrosine kinase. The protein regulates multiple cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. Missense mutations, nonsense mutations, silent mutations, and frameshift deletions and insertions are observed in cancers such as esophageal cancer, skin cancer, and stomach cancer.

PTPRD is altered in 4.70% of all cancers with lung adenocarcinoma, breast invasive ductal carcinoma, cutaneous melanoma, colon adenocarcinoma, and endometrial endometrioid adenocarcinoma having the greatest prevalence of alterations [3].

PTPRD GENIE Cases - Top Diseases

The most common alterations in PTPRD are PTPRD Mutation (4.55%), PTPRD Loss (0.41%), PTPRD Amplification (0.28%), PTPRD E406K (0.04%), and PTPRD S431L (0.04%) [3].

PTPRD GENIE Cases - Top Alterations


1. Hart R and Prlic A. Universal Transcript Archive Repository. Version uta_20180821. San Francisco CA: Github;2015. https://github.com/biocommons/uta

2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.

3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

4. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.