Biomarkers /

PTPRK

Back to Biomarkers List
Associated Diseases

Overview

Location [1]
6q22.33
Protein [2]
Receptor-type tyrosine-protein phosphatase kappa
Synonyms [1]
R-PTP-kappa

PTPRK is altered in 0.30% of all cancers with colon adenocarcinoma, conventional glioblastoma multiforme, cutaneous melanoma, colorectal adenocarcinoma, and melanoma having the greatest prevalence of alterations [3].

PTPRK GENIE Cases - Top Diseases

The most common alterations in PTPRK are PTPRK-RSPO3 Fusion (0.10%), PTPRK R331Q (0.13%), PTPRK V769I (0.18%), PTPRK A1116S (0.09%), and PTPRK A1242V (0.07%) [3].

PTPRK GENIE Cases - Top Alterations

References

1. Hart R and Prlic A. Universal Transcript Archive Repository. Version uta_20180821. San Francisco CA: Github;2015. https://github.com/biocommons/uta

2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.

3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

4. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.