Biomarkers /

PTPRS

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Overview

Location [1]
19p13.3
Protein [2]
Receptor-type tyrosine-protein phosphatase S
Synonyms [1]
PTPSIGMA, R-PTP-sigma, R-PTP-S

PTPRS is altered in 3.18% of all cancers with colon adenocarcinoma, lung adenocarcinoma, endometrial endometrioid adenocarcinoma, cutaneous melanoma, and breast invasive ductal carcinoma having the greatest prevalence of alterations [3].

PTPRS GENIE Cases - Top Diseases

The most common alterations in PTPRS are PTPRS Loss (0.15%), PTPRS V1025fs (0.13%), PTPRS Amplification (0.10%), PTPRS P622fs (0.07%), and PTPRS S1773L (0.03%) [3].

PTPRS GENIE Cases - Top Alterations

References

1. Hart R and Prlic A. Universal Transcript Archive Repository. Version uta_20180821. San Francisco CA: Github;2015. https://github.com/biocommons/uta

2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.

3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

4. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.