Biomarkers /

PTPRZ1

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Associated Diseases

Overview

Location [1]
7q31.32
Protein [2]
Receptor-type tyrosine-protein phosphatase zeta
Synonyms [1]
RPTPbeta, HPTPzeta, PTP18, HPTPZ, PTPZ, RPTPB, PTP-ZETA, phosphacan, PTPRZ, R-PTP-zeta-2

PTPRZ1 is altered in 0.08% of all cancers with lung adenocarcinoma, conventional glioblastoma multiforme, breast invasive ductal carcinoma, colon adenocarcinoma, and diffuse glioma having the greatest prevalence of alterations [3].

PTPRZ1 GENIE Cases - Top Diseases

The most common alterations in PTPRZ1 are PTPRZ1-MET Fusion (0.08%), PTPRZ1-BRAF Fusion (0.03%), PTPRZ1-EPHB1 Fusion (0.01%), and PTPRZ1-ESR1 Fusion (0.02%) [3].

PTPRZ1 GENIE Cases - Top Alterations

References

1. Hart R and Prlic A. Universal Transcript Archive Repository. Version uta_20180821. San Francisco CA: Github;2015. https://github.com/biocommons/uta

2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.

3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

4. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.