Overview

Location [1]
3p25.2
Pathway
MAP kinase signaling
Protein [2]
RAF proto-oncogene serine/threonine-protein kinase
Synonyms [1]
Raf-1, NS5, c-Raf, CRAF, CMD1NN

Raf-1 proto-oncogene, serine/threonine kinase (RAF1, also known as CRAF) is a gene that encodes a protein that functions downstream of RAS and activates MEK1 and MEK2. Fusions, rearrangements, missense mutations, nonsense mutations, and silent mutations are observed in cancers such as endometrial cancer, intestinal cancer, and stomach cancer.

RAF1 is altered in 1.25% of all cancers with colorectal adenocarcinoma, non-small cell lung carcinoma, melanoma, bladder carcinoma, and breast carcinoma having the greatest prevalence of alterations [3].

RAF1 GENIE Cases - Top Diseases

The most common alterations in RAF1 are RAF1 Mutation (0.98%), RAF1 Amplification (0.25%), RAF1 S257L (0.10%), RAF1 R391W (0.03%), and RAF1 S259F (0.03%) [3].

RAF1 GENIE Cases - Top Alterations

Significance of RAF1 in Diseases

Malignant Solid Tumor +

Non-Small Cell Lung Carcinoma +

Non-Hodgkin Lymphoma +

Glioma +

Melanoma +

Colorectal Carcinoma +

Neuroblastoma +

Pancreatic Carcinoma +

Multiple Myeloma +

Neurofibromatosis Type 1 +

Urothelial Carcinoma +

Endometrial Carcinoma +

Nasopharyngeal Carcinoma +

Rhabdomyosarcoma +

Gastric Carcinoma +

Adenocarcinoma Of The Gastroesophageal Junction +

Esophageal Carcinoma +

Lymphoma +

Soft Tissue Sarcoma +

Gastrointestinal Stromal Tumor +

Squamous Cell Lung Carcinoma +

Hepatocellular Carcinoma +

Breast Carcinoma +

Renal Cell Carcinoma +

Hepatobiliary Neoplasm +

Histiocytic And Dendritic Cell Neoplasm +

Lip And Oral Cavity Carcinoma +

Malignant Laryngeal Neoplasm +

Malignant Peripheral Nerve Sheath Tumor +

Malignant Salivary Gland Neoplasm +

Nasal Cavity And Paranasal Sinus Carcinoma +

Oropharyngeal Carcinoma +

Ovarian Carcinoma +

Pancreatic Ductal Adenocarcinoma +

Rhabdoid Tumor +

Schwannoma +

Thyroid Gland Carcinoma +

References

1. Hart R and Prlic A. Universal Transcript Archive Repository. Version uta_20170629. San Francisco CA: Github;2015. https://github.com/biocommons/uta

2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.

3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 4. This dataset does not represent the totality of the genetic landscape; see paper for more information.

4. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.