RAN binding protein 2 (RANBP2) is a gene that encodes a protein that functions in the Ran-GTPase cycle. Missense mutations, synonymous mutations, nonsense mutations, frameshift deletions, and frameshift insertions are observed in cancers such as stomach cancer, skin cancer, and colon cancer.
RANBP2 is altered in 0.33% of all cancers with lung adenocarcinoma, breast invasive ductal carcinoma, colon adenocarcinoma, cutaneous melanoma, and bladder urothelial carcinoma having the greatest prevalence of alterations .
The most common alterations in RANBP2 are RANBP2-FGFR1 Fusion (0.22%), RANBP2-ALK Fusion (0.03%), RANBP2 L811R (0.15%), RANBP2 A573G (0.11%), and RANBP2 C1744Y (0.12%) .
2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.
3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.