RNA binding motif protein 10 (RBM10) is a gene that encodes a protein that may be involved in regulating alternative splicing. Missense mutations, nonsense mutations, synonymous mutations, frameshift deletions, inframe deletions, and frameshift insertions are observed in cancers such as colon cancer, thymic cancer, and lung cancer.
RBM10 is altered in 3.47% of all cancers with lung adenocarcinoma, colon adenocarcinoma, bladder urothelial carcinoma, breast invasive ductal carcinoma, and endometrial endometrioid adenocarcinoma having the greatest prevalence of alterations .
The most common alterations in RBM10 are RBM10 Loss (0.33%), RBM10 Amplification (0.24%), RBM10 X565_splice (0.04%), RBM10 X387_splice (0.03%), and RBM10 D120E (0.03%) .
2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.
3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.