Location [1]
Protein [2]
Proto-oncogene c-Rel
Synonyms [1]

V-rel avian reticuloendotheliosis viral oncogene homolog (REL) is a gene that encodes a protein that functions in regulation of genes involved in apoptosis, inflammation, the immune response, and oncogenesis. Missense mutations, silent mutations, nonsense mutations, and frameshift insertions are observed in cancers such as colon cancer, cervical cancer, and endometrial cancer.

REL is altered in 0.95% of all cancers with lung adenocarcinoma, colon adenocarcinoma, diffuse large B-cell lymphoma, not otherwise specified, endometrial endometrioid adenocarcinoma, and breast invasive ductal carcinoma having the greatest prevalence of alterations [3].

REL GENIE Cases - Top Diseases

The most common alterations in REL are REL Amplification (0.18%), REL N424S (0.08%), REL R108* (0.02%), REL R313H (0.02%), and REL S440L (0.01%) [3].

REL GENIE Cases - Top Alterations


1. Hart R and Prlic A. Universal Transcript Archive Repository. Version uta_20180821. San Francisco CA: Github;2015. https://github.com/biocommons/uta

2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.

3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

4. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.