Overview

Location [1]
11q13.1
Protein [2]
Transcription factor p65
Synonyms [1]
CMCU, p65, NFKB3

RELA is altered in 0.43% of all cancers with lung adenocarcinoma, anaplastic ependymoma, breast invasive ductal carcinoma, colon adenocarcinoma, and melanoma having the greatest prevalence of alterations [3].

RELA GENIE Cases - Top Diseases

The most common alterations in RELA are RELA Fusion (0.06%), RELA Q442P (0.06%), RELA-C11ORF95 Fusion (0.04%), RELA A264V (0.03%), and RELA D167N (0.03%) [3].

RELA GENIE Cases - Top Alterations

Significance of RELA in Diseases

Ependymoma +

Ependymoma, RELA Fusion-Positive +

Anaplastic Ependymoma +

Anaplastic Oligodendroglioma +

Diffuse Midline Glioma, H3 K27M-Mutant +

Malignant Glioma +

Glioblastoma +

Diffuse Glioma +

Anaplastic Astrocytoma +

Anaplastic Astrocytoma, IDH-Mutant +

Anaplastic Oligodendroglioma, IDH-Mutant And 1p/19q-Codeleted +

Anaplastic Pleomorphic Xanthoastrocytoma +

Atypical Teratoid/Rhabdoid Tumor +

Central Nervous System Embryonal Neoplasm +

Central Nervous System Ganglioneuroblastoma +

Central Nervous System Neuroblastoma +

Embryonal Tumor With Multilayered Rosettes, C19MC-Altered +

Embryonal Tumor With Multilayered Rosettes, Not Otherwise Specified +

High-Grade Glioma, NOS +

Medulloblastoma +

Medulloblastoma, Non-WNT/Non-SHH +

Medulloblastoma, SHH-Activated +

Medulloblastoma, WNT-Activated +

Medulloepithelioma +

References

1. Hart R and Prlic A. Universal Transcript Archive Repository. Version uta_20180821. San Francisco CA: Github;2015. https://github.com/biocommons/uta

2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.

3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

4. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.