Overview

Location [1]
11q13.1
Protein [2]
Ribosomal protein S6 kinase alpha-4
Synonyms [1]
RSK-B, S6K-alpha-4, MSK2

RPS6KA4 is altered in 1.39% of all cancers with colon adenocarcinoma, lung adenocarcinoma, breast invasive ductal carcinoma, endometrial endometrioid adenocarcinoma, and prostate adenocarcinoma having the greatest prevalence of alterations [3].

RPS6KA4 GENIE Cases - Top Diseases

The most common alterations in RPS6KA4 are RPS6KA4 Loss (0.12%), RPS6KA4 Amplification (0.08%), RPS6KA4 S236L (0.02%), RPS6KA4 R529H (0.01%), and RPS6KA4 R629C (0.01%) [3].

RPS6KA4 GENIE Cases - Top Alterations

References

1. Hart R and Prlic A. Universal Transcript Archive Repository. Version uta_20180821. San Francisco CA: Github;2015. https://github.com/biocommons/uta

2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.

3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

4. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.