Biomarkers /

SMARCC1

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Overview

Location [1]
3p21.31
Protein [2]
SWI/SNF complex subunit SMARCC1
Synonyms [1]
SRG3, BAF155, SWI3, Rsc8, CRACC1

SMARCC1 is altered in 0.11% of all cancers with breast invasive ductal carcinoma, mixed lobular and ductal breast carcinoma, breast neoplasm, and prostate adenocarcinoma having the greatest prevalence of alterations [3].

SMARCC1 GENIE Cases - Top Diseases

The most common alterations in SMARCC1 are SMARCC1 Loss (0.17%), SMARCC1 D250G (0.08%), SMARCC1-SETD2 Fusion (0.01%), SMARCC1 A322V (0.04%), and SMARCC1 A521V (0.04%) [3].

SMARCC1 GENIE Cases - Top Alterations

References

1. Hart R and Prlic A. Universal Transcript Archive Repository. Version uta_20180821. San Francisco CA: Github;2015. https://github.com/biocommons/uta

2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.

3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

4. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.