Overview

Suppressor of cytokine signaling 1 (SOCS1) is a gene that encodes a protein that functions as a cytokine-inducible negative regulator of cytokine signaling. Missense mutations, nonsense mutations, silent mutations, frameshift deletions, and in-frame deletions and insertions are observed in cancers such as hematopoietic and lymphoid cancers, intestinal cancer, and lung cancer.

SOCS1 is altered in 0.87% of all cancers with diffuse large B-cell lymphoma, not otherwise specified, lung adenocarcinoma, follicular lymphoma, breast invasive ductal carcinoma, and colon adenocarcinoma having the greatest prevalence of alterations [3].

The most common alterations in SOCS1 are SOCS1 Amplification (0.21%), SOCS1 Loss (0.05%), SOCS1 Fusion (0.10%), SOCS1 A49_P50del (0.06%), and SOCS1 M1? (0.02%) [3].

References

1. Hart R and Prlic A. Universal Transcript Archive Repository. Version uta_20180821. San Francisco CA: Github;2015. https://github.com/biocommons/uta

2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.

3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

4. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.