Associated Genetic Biomarkers
Associated Diseases
Associated Pathways

Overview

Location [1]
12q13.3
Pathway
JAK/STAT signaling
Protein [2]
Signal transducer and activator of transcription 2
Synonyms [1]
P113, ISGF-3, IMD44, STAT113, PTORCH3

Signal transducer and activator of transcription 2 (STAT2) is a gene that encodes a member of the STAT protein family that functions as a transcription activator when translocated to the nucleus of a cell. Missense mutations, nonsense mutations, silent mutations, and frameshift deletions and insertions are observed in cancers such as cervical cancer, endometrial cancer, and intestinal cancer.

STAT2 is altered in 0.02% of all cancers with ovarian epithelial tumor having the greatest prevalence of alterations [3].

STAT2 GENIE Cases - Top Diseases

The most common alteration in STAT2 is STAT2-ERBB3 Fusion (0.02%) [3].

STAT2 GENIE Cases - Top Alterations

Significance of STAT2 in Diseases

Malignant Solid Tumor +

References

1. Hart R and Prlic A. Universal Transcript Archive Repository. Version uta_20180821. San Francisco CA: Github;2015. https://github.com/biocommons/uta

2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.

3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

4. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.