Associated Genetic Biomarkers
TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa (TAF15) is a gene that encodes a protein that functions in RNA polymerase II gene transcription as a component of a multi-subunit transcription initiation factor TFIID complex. Fusions are observed in this gene.
TAF15 is altered in 0.07% of all cancers with pancreatic adenocarcinoma, breast invasive ductal carcinoma, sarcoma, NOS, anaplastic meningioma, and angiosarcoma having the greatest prevalence of alterations .
The most common alterations in TAF15 are TAF15 G478_G485del (2.43%), TAF15 S442G (0.61%), TAF15 G424_S432del (0.30%), TAF15 G473R (0.30%), and TAF15 G520_R526del (0.30%) .
TAF15 status serves as an inclusion eligibility criteria in 1 clinical trial, of which 1 is open and 0 are closed. Of the trial that contains TAF15 status as an inclusion criterion, 1 is phase 1 (1 open).
Trials with TAF15 status in the inclusion eligibility criteria most commonly target sarcoma .
The most frequent alteration to serve as an inclusion eligibility criterion is TAF15 Fusion .
Seclidemstat is the most frequent therapy in trials with TAF15 as an inclusion criteria .
Significance of TAF15 in Diseases
Ewing Sarcoma +
TAF15 is an inclusion criterion in 1 clinical trial for Ewing sarcoma, of which 1 is open and 0 are closed. Of the trial that contains TAF15 status and Ewing sarcoma as inclusion criteria, 1 is phase 1 (1 open) .
Myxoid Liposarcoma +
TAF15 is an inclusion criterion in 1 clinical trial for myxoid liposarcoma, of which 1 is open and 0 are closed. Of the trial that contains TAF15 status and myxoid liposarcoma as inclusion criteria, 1 is phase 1 (1 open) .
2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.
3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.