Associated Genetic Biomarkers
Associated Diseases


Location [1]
Protein [2]
TATA-binding protein-associated factor 2N
Synonyms [1]
TAFII68, Npl3, RBP56, TAF2N

TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa (TAF15) is a gene that encodes a protein that functions in RNA polymerase II gene transcription as a component of a multi-subunit transcription initiation factor TFIID complex. Fusions are observed in this gene.

TAF15 is altered in 0.07% of all cancers with pancreatic adenocarcinoma, breast invasive ductal carcinoma, sarcoma, NOS, anaplastic meningioma, and angiosarcoma having the greatest prevalence of alterations [3].

TAF15 GENIE Cases - Top Diseases

The most common alterations in TAF15 are TAF15 G478_G485del (2.43%), TAF15 S442G (0.61%), TAF15 G424_S432del (0.30%), TAF15 G473R (0.30%), and TAF15 G520_R526del (0.30%) [3].

TAF15 GENIE Cases - Top Alterations

Significance of TAF15 in Diseases

Sarcoma +

Ewing Sarcoma +

Myxoid Liposarcoma +


1. Hart R and Prlic A. Universal Transcript Archive Repository. Version uta_20180821. San Francisco CA: Github;2015.

2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.

3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

4. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.