Associated Genetic Biomarkers
T-box 3 (TBX3) is a gene that encodes a transcriptional repressor protein that functions in the regulation of developmental processes. Missense mutations, synonymous mutations, frameshift insertions, frameshift deletions, nonsense mutations, and inframe deletions are observed in cancers such as colon cancer, skin cancer, and breast cancer.
TBX3 is altered in 2.81% of all cancers with breast invasive ductal carcinoma, lung adenocarcinoma, breast invasive lobular carcinoma, prostate adenocarcinoma, and colon adenocarcinoma having the greatest prevalence of alterations .
The most common alterations in TBX3 are TBX3 Mutation (1.80%), TBX3 Amplification (0.45%), TBX3 Loss (0.04%), TBX3 X367_splice (0.03%), and TBX3 Q590* (0.02%) .
TBX3 status serves as an inclusion eligibility criteria in 1 clinical trial, of which 0 are open and 1 is closed. Of the trial that contains TBX3 status as an inclusion criterion, 1 is phase 1 (0 open).
Trials with TBX3 status in the inclusion eligibility criteria most commonly target bladder carcinoma, breast carcinoma, colorectal carcinoma, head and neck carcinoma, and lymphoma .
The most frequent alteration to serve as an inclusion eligibility criterion is TBX3 Mutation .
Extended release flucytosine and vocimagene amiretrorepvec are the most frequent therapies in trials with TBX3 as an inclusion criteria .
Significance of TBX3 in Diseases
Non-Small Cell Lung Carcinoma +
TBX3 is altered in 3.55% of non-small cell lung carcinoma patients .
TBX3 is an inclusion criterion in 1 clinical trial for non-small cell lung carcinoma, of which 0 are open and 1 is closed. Of the trial that contains TBX3 status and non-small cell lung carcinoma as inclusion criteria, 1 is phase 1 (0 open) .
Bladder Carcinoma +
Breast Carcinoma +
Colorectal Carcinoma +
Malignant Solid Tumor +
Head And Neck Carcinoma +
Ovarian Carcinoma +
Pancreatic Carcinoma +
Anaplastic Astrocytoma +
2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.
3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.