Biomarkers /

TCF12

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Overview

Location [1]
15q21.3
Protein [2]
Transcription factor 12
Synonyms [1]
HTF4, CRS3, bHLHb20, HsT17266, HEB, p64, TCF-12

TCF12 is altered in 0.11% of all cancers with endometrial endometrioid adenocarcinoma, high grade ovarian serous adenocarcinoma, bladder urothelial carcinoma, pancreatic adenocarcinoma, and cervical squamous cell carcinoma having the greatest prevalence of alterations [3].

TCF12 GENIE Cases - Top Diseases

The most common alterations in TCF12 are TCF12 A330T (0.39%), TCF12 A410V (0.39%), TCF12 A625V (0.20%), TCF12 D350N (0.22%), and TCF12 E599V (0.22%) [3].

TCF12 GENIE Cases - Top Alterations

References

1. Hart R and Prlic A. Universal Transcript Archive Repository. Version uta_20180821. San Francisco CA: Github;2015. https://github.com/biocommons/uta

2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.

3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

4. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.