Overview

Location [1]
9p21.2
Protein [2]
Angiopoietin-1 receptor
Synonyms [1]
VMCM, TIE2, TIE-2, VMCM1, CD202B, GLC3E

TEK is altered in 1.67% of all cancers with lung adenocarcinoma, cutaneous melanoma, conventional glioblastoma multiforme, breast invasive ductal carcinoma, and colon adenocarcinoma having the greatest prevalence of alterations [3].

TEK GENIE Cases - Top Diseases

The most common alterations in TEK are TEK Mutation (1.46%), TEK Loss (1.18%), TEK Amplification (0.17%), TEK P417fs (0.03%), and TEK A933T (0.02%) [3].

TEK GENIE Cases - Top Alterations

Significance of TEK in Diseases

Nasal Cavity And Paranasal Sinus Carcinoma +

Nasopharyngeal Carcinoma +

Oropharyngeal Carcinoma +

Urothelial Carcinoma +

Gastric Carcinoma +

Malignant Solid Tumor +

Non-Small Cell Lung Carcinoma +

Gastrointestinal Stromal Tumor +

Pancreatic Carcinoma +

Adenocarcinoma Of The Gastroesophageal Junction +

Prostate Carcinoma +

Hepatobiliary Neoplasm +

Malignant Hepatobiliary Neoplasm +

Malignant Salivary Gland Neoplasm +

Lip And Oral Cavity Carcinoma +

Esophageal Carcinoma +

Malignant Laryngeal Neoplasm +

References

1. Hart R and Prlic A. Universal Transcript Archive Repository. Version uta_20180821. San Francisco CA: Github;2015. https://github.com/biocommons/uta

2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.

3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

4. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.