Tet methylcytosine dioxygenase 1 (TET1) is a gene that encodes a protein that functions as a dioxygenase that catalyzes the conversion of 5-methylcytosine to 5-hydroxymethylcytosine. The protein is also involved in active DNA demethylation. Fusions, missense mutations, nonsense mutations, and silent mutations are observed in cancers such as breast cancer, intestinal cancer, and ovarian cancer.
TET1 is altered in 2.19% of all cancers with lung adenocarcinoma, colon adenocarcinoma, endometrial endometrioid adenocarcinoma, prostate adenocarcinoma, and breast invasive ductal carcinoma having the greatest prevalence of alterations .
The most common alterations in TET1 are TET1 Amplification (0.15%), TET1 Loss (0.06%), TET1 R81H (0.03%), TET1 R107Q (0.02%), and TET1 R590Q (0.02%) .
2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.
3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.