Location [1]
Protein [2]
Transmembrane protease serine 2 catalytic chain
Synonyms [1]

Transmembrane protease, serine 2 (TMPRSS2) is a gene that encodes a protein that is a member of the serine protease family. The protein is involved in several physiological and pathological processes. Fusions, rearrangements, missense mutations, and silent mutations are observed in cancers such as kidney cancer, ovarian cancer, and skin cancer.

TMPRSS2 is altered in 2.24% of all cancers with prostate adenocarcinoma, lung adenocarcinoma, cutaneous melanoma, breast invasive ductal carcinoma, and colon adenocarcinoma having the greatest prevalence of alterations [3].

TMPRSS2 GENIE Cases - Top Diseases

The most common alterations in TMPRSS2 are TMPRSS2-ERG Fusion (1.22%), TMPRSS2 Amplification (0.15%), TMPRSS2 Loss (0.10%), TMPRSS2-ETV1 Fusion (0.08%), and TMPRSS2-ETV4 Fusion (0.09%) [3].

TMPRSS2 GENIE Cases - Top Alterations


1. Hart R and Prlic A. Universal Transcript Archive Repository. Version uta_20180821. San Francisco CA: Github;2015. https://github.com/biocommons/uta

2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.

3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

4. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.