Overview

Location [1]
8p21.3
Protein [2]
Tumor necrosis factor receptor superfamily member 10B
Synonyms [1]
TRICK2B, KILLER, KILLER/DR5, CD262, DR5, TRAILR2, TRAIL-R2, TRICK2, TRICK2A, ZTNFR9, TRICKB

TNFRSF10B is altered in 0.02% of all cancers with esophageal adenocarcinoma and lung adenocarcinoma having the greatest prevalence of alterations [3].

TNFRSF10B GENIE Cases - Top Diseases

The most common alterations in TNFRSF10B are TNFRSF10B-FGFR1 Fusion (0.02%) and TNFRSF10B-NRG1 Fusion (0.04%) [3].

TNFRSF10B GENIE Cases - Top Alterations

Significance of TNFRSF10B in Diseases

Esophageal Carcinoma +

Gastric Carcinoma +

Glioblastoma +

Hepatocellular Carcinoma +

References

1. Hart R and Prlic A. Universal Transcript Archive Repository. Version uta_20180821. San Francisco CA: Github;2015. https://github.com/biocommons/uta

2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.

3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

4. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.