Location [1]
Protein [2]
Tumor necrosis factor receptor superfamily member 14
Synonyms [1]

Tumor necrosis factor receptor superfamily, member 14 (TNFRSF14) is a gene that encodes a protein that belongs to the tumor necrosis factor (TNF) superfamily. The protein functions in the activation of inflammatory and inhibitory T-cell immune responses. Missense mutations, nonsense mutations, frameshift deletions and insertions, and in-frame insertions are observed in cancers such as hematopoietic and lymphoid cancers and kidney cancer.

TNFRSF14 is altered in 1.22% of all cancers with follicular lymphoma, diffuse large B-cell lymphoma, not otherwise specified, lung adenocarcinoma, colon adenocarcinoma, and conventional glioblastoma multiforme having the greatest prevalence of alterations [3].

TNFRSF14 GENIE Cases - Top Diseases

The most common alterations in TNFRSF14 are TNFRSF14 Loss (0.44%), TNFRSF14 Amplification (0.11%), TNFRSF14 W12* (0.14%), TNFRSF14 X102_splice (0.06%), and TNFRSF14 M1? (0.05%) [3].

TNFRSF14 GENIE Cases - Top Alterations


1. Hart R and Prlic A. Universal Transcript Archive Repository. Version uta_20180821. San Francisco CA: Github;2015. https://github.com/biocommons/uta

2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.

3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

4. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.