Overview

Location [1]
1p13.2
Protein [2]
E3 ubiquitin-protein ligase TRIM33
Synonyms [1]
PTC7, ECTO, RFG7, TIFGAMMA, TIF1GAMMA, TF1G, TIF1G

TRIM33 is altered in 0.13% of all cancers with lung adenocarcinoma, breast invasive ductal carcinoma, bladder urothelial carcinoma, high grade ovarian serous adenocarcinoma, and thyroid gland papillary carcinoma having the greatest prevalence of alterations [3].

TRIM33 GENIE Cases - Top Diseases

The most common alterations in TRIM33 are TRIM33-RET Fusion (0.10%), TRIM33 K5T (1.05%), TRIM33-ERBB4 Fusion (0.02%), TRIM33 K5Q (0.77%), and TRIM33 M1? (0.77%) [3].

TRIM33 GENIE Cases - Top Alterations

References

1. Hart R and Prlic A. Universal Transcript Archive Repository. Version uta_20180821. San Francisco CA: Github;2015. https://github.com/biocommons/uta

2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.

3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

4. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.