Overview

Location [1]
22q12.1
Protein [2]
Tetratricopeptide repeat protein 28
Synonyms [1]
TPRBK

TTC28 is altered in 0.07% of all cancers with cholangiocarcinoma, breast invasive ductal carcinoma, colon adenocarcinoma, adenocarcinoma of unknown primary, and adenocarcinoma of the gastroesophageal junction having the greatest prevalence of alterations [3].

TTC28 GENIE Cases - Top Diseases

The most common alterations in TTC28 are TTC28-CHEK2 Fusion (0.01%), TTC28-APC Fusion (0.03%), TTC28-FGFR2 Fusion (0.00%), and TTC28-NRG1 Fusion (0.02%) [3].

TTC28 GENIE Cases - Top Alterations

References

1. Hart R and Prlic A. Universal Transcript Archive Repository. Version uta_20180821. San Francisco CA: Github;2015. https://github.com/biocommons/uta

2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.

3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

4. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.