Overview

Location [1]
15q15.1
Protein [2]
Tyrosine-protein kinase receptor TYRO3
Synonyms [1]
BYK, Etk-2, Tif, Rek, Dtk, RSE, Sky

TYRO3 is altered in 0.04% of all cancers with lung adenocarcinoma, breast invasive ductal carcinoma, colon adenocarcinoma, oligodendroglioma, and ovarian serous adenocarcinoma having the greatest prevalence of alterations [3].

TYRO3 GENIE Cases - Top Diseases

The most common alterations in TYRO3 are TYRO3 Mutation (2.37%), TYRO3 K318M (0.30%), TYRO3 P21R (0.30%), TYRO3 R452* (0.30%), and TYRO3 R678W (0.30%) [3].

TYRO3 GENIE Cases - Top Alterations

Significance of TYRO3 in Diseases

Malignant Solid Tumor +

References

1. Hart R and Prlic A. Universal Transcript Archive Repository. Version uta_20180821. San Francisco CA: Github;2015. https://github.com/biocommons/uta

2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.

3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

4. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.