Biomarkers /

VCL

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Associated Diseases

Overview

Location [1]
10q22.2
Protein [2]
Vinculin
Synonyms [1]
HEL114, MVCL, CMD1W, MV, CMH15

VCL is altered in 0.08% of all cancers with lung adenocarcinoma, cancer of unknown primary, NOS, acute myeloid leukemia, anal squamous cell carcinoma, and cancer of unknown primary having the greatest prevalence of alterations [3].

VCL GENIE Cases - Top Diseases

The most common alterations in VCL are VCL-ALK Fusion (0.08%), VCL-NTRK2 Fusion (0.04%), and VCL-FGFR2 Fusion (0.01%) [3].

VCL GENIE Cases - Top Alterations

References

1. Hart R and Prlic A. Universal Transcript Archive Repository. Version uta_20180821. San Francisco CA: Github;2015. https://github.com/biocommons/uta

2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.

3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

4. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.