Overview

Location [1]
17p13.1
Protein [2]
Telomerase Cajal body protein 1
Synonyms [1]
WDR79, DKCB3, TCAB1

WRAP53 is altered in 0.03% of all cancers with pancreatic adenocarcinoma, adrenal cortex carcinoma, diffuse large B-cell lymphoma, not otherwise specified, esophagogastric carcinoma, and medulloblastoma having the greatest prevalence of alterations [3].

WRAP53 GENIE Cases - Top Diseases

The most common alterations in WRAP53 are WRAP53 Fusion (0.02%), WRAP53-TP53 Fusion (0.01%), WRAP53-ASXL2 Fusion (0.04%), WRAP53-MCF2L2 Fusion (0.02%), and WRAP53-SHBG Fusion (0.02%) [3].

WRAP53 GENIE Cases - Top Alterations

References

1. Hart R and Prlic A. Universal Transcript Archive Repository. Version uta_20180821. San Francisco CA: Github;2015. https://github.com/biocommons/uta

2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.

3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

4. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.