Location [1]
Protein [2]
DNA repair protein XRCC3
Synonyms [1]

XRCC3 is altered in 1.27% of all cancers with colon adenocarcinoma, endometrial endometrioid adenocarcinoma, lung adenocarcinoma, glioblastoma, and melanoma having the greatest prevalence of alterations [3].

XRCC3 GENIE Cases - Top Diseases

The most common alterations in XRCC3 are XRCC3 Mutation (1.15%), XRCC3 T52M (0.08%), XRCC3 A268T (0.13%), XRCC3 E182K (0.05%), and XRCC3 E45K (0.03%) [3].

XRCC3 GENIE Cases - Top Alterations

Significance of XRCC3 in Diseases

Urothelial Carcinoma +


1. Hart R and Prlic A. Universal Transcript Archive Repository. Version uta_20180821. San Francisco CA: Github;2015. https://github.com/biocommons/uta

2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.

3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

4. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.