Biomarkers /

YWHAE

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Overview

Location [1]
17p13.3
Protein [2]
14-3-3 protein epsilon
Synonyms [1]
HEL2, KCIP-1, 14-3-3E, MDS, MDCR

YWHAE is altered in 0.09% of all cancers with lung adenocarcinoma, breast invasive ductal carcinoma, dedifferentiated liposarcoma, conventional glioblastoma multiforme, and cutaneous melanoma having the greatest prevalence of alterations [3].

YWHAE GENIE Cases - Top Diseases

The most common alterations in YWHAE are YWHAE-ROS1 Fusion (0.10%), YWHAE-NUTM2B Fusion (0.01%), YWHAE A191V (0.07%), YWHAE D238G (0.07%), and YWHAE E241K (0.02%) [3].

YWHAE GENIE Cases - Top Alterations

References

1. Hart R and Prlic A. Universal Transcript Archive Repository. Version uta_20180821. San Francisco CA: Github;2015. https://github.com/biocommons/uta

2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.

3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

4. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.