Biomarkers /

ZFHX3

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Overview

Location [1]
16q22.2-q22.3
Protein [2]
Zinc finger homeobox protein 3
Synonyms [1]
ATBF1, ZFH-3, ZNF927, C16orf47, ATBT

ZFHX3 is altered in 5.37% of all cancers with colon adenocarcinoma, prostate adenocarcinoma, lung adenocarcinoma, endometrial endometrioid adenocarcinoma, and cutaneous melanoma having the greatest prevalence of alterations [3].

ZFHX3 GENIE Cases - Top Diseases

The most common alterations in ZFHX3 are ZFHX3 Loss (0.38%), ZFHX3 Amplification (0.08%), ZFHX3 R2950H (0.04%), ZFHX3 Q1794del (0.31%), and ZFHX3 A784del (0.02%) [3].

ZFHX3 GENIE Cases - Top Alterations

References

1. Hart R and Prlic A. Universal Transcript Archive Repository. Version uta_20180821. San Francisco CA: Github;2015. https://github.com/biocommons/uta

2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.

3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

4. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.