Zinc finger protein 217 (ZNF217) is a gene that encodes a protein that functions as a transcriptional repressor. Missense mutations, nonsense mutations, silent mutations, and frameshift deletions are observed in cancers such as intestinal cancer, skin cancer, and stomach cancer.
ZNF217 is altered in 2.74% of all cancers with colon adenocarcinoma, lung adenocarcinoma, breast invasive ductal carcinoma, invasive breast carcinoma, and endometrial endometrioid adenocarcinoma having the greatest prevalence of alterations .
The most common alterations in ZNF217 are ZNF217 Amplification (0.84%), ZNF217 A207V (0.06%), ZNF217 L748W (0.04%), ZNF217 Fusion (0.04%), and ZNF217 K741R (0.04%) .
2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.
3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.