Location [1]
Protein [2]
Zinc finger protein 217
Synonyms [1]

Zinc finger protein 217 (ZNF217) is a gene that encodes a protein that functions as a transcriptional repressor. Missense mutations, nonsense mutations, silent mutations, and frameshift deletions are observed in cancers such as intestinal cancer, skin cancer, and stomach cancer.

ZNF217 is altered in 2.74% of all cancers with colon adenocarcinoma, lung adenocarcinoma, breast invasive ductal carcinoma, invasive breast carcinoma, and endometrial endometrioid adenocarcinoma having the greatest prevalence of alterations [3].

ZNF217 GENIE Cases - Top Diseases

The most common alterations in ZNF217 are ZNF217 Amplification (0.84%), ZNF217 A207V (0.06%), ZNF217 L748W (0.04%), ZNF217 Fusion (0.04%), and ZNF217 K741R (0.04%) [3].

ZNF217 GENIE Cases - Top Alterations


1. Hart R and Prlic A. Universal Transcript Archive Repository. Version uta_20180821. San Francisco CA: Github;2015. https://github.com/biocommons/uta

2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.

3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

4. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.