Biomarkers /
ZNF384
Overview
Zinc finger protein 384 (ZNF384) is a gene that encodes a protein that functions as a zinc finger transcription factor. The protein also binds and regulates the promoters of the extracellular matrix genes. Fusions, missense mutations, nonsense mutations, silent mutations, frameshift deletions, and in-frame deletions are observed in cancers such as endometrial cancer, intestinal cancer, and upper aerodigestive tract cancer.
ZNF384 is altered in 0.22% of all cancers with breast invasive ductal carcinoma, cervical squamous cell carcinoma, glioblastoma, lung adenocarcinoma, and bladder urothelial carcinoma having the greatest prevalence of alterations [3].
The most common alterations in ZNF384 are ZNF384 A157V (0.77%), ZNF384 D74E (0.77%), ZNF384 E39Q (0.77%), ZNF384 E3D (0.77%), and ZNF384 G154V (0.77%) [3].
References
1. Hart R and Prlic A. Universal Transcript Archive Repository. Version uta_20180821. San Francisco CA: Github;2015. https://github.com/biocommons/uta
2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.
3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.
4. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.