Biomarkers /

ZNRF3

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Associated Diseases

Overview

Location [1]
22q12.1
Protein [2]
E3 ubiquitin-protein ligase ZNRF3
Synonyms [1]
RNF203, BK747E2.3

ZNRF3 is altered in 0.63% of all cancers with colon adenocarcinoma, lung adenocarcinoma, endometrial endometrioid adenocarcinoma, melanoma, and adenocarcinoma of unknown primary having the greatest prevalence of alterations [3].

ZNRF3 GENIE Cases - Top Diseases

The most common alterations in ZNRF3 are ZNRF3 Loss (0.15%), ZNRF3 P634L (0.07%), ZNRF3 G558S (0.08%), ZNRF3 Fusion (0.04%), and ZNRF3 G792E (0.04%) [3].

ZNRF3 GENIE Cases - Top Alterations

References

1. Hart R and Prlic A. Universal Transcript Archive Repository. Version uta_20180821. San Francisco CA: Github;2015. https://github.com/biocommons/uta

2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.

3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

4. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.