Abl-interactor 1 (ABI1) is a gene that encodes an adapter protein that functions in signal transduction, the regulation of actin polymerization, and cytoskeletal remodeling. These functions are achieved via the interaction of the protein with Abelson tyrosine kinases. Fusions, missense mutations, nonsense mutations, silent mutations, frameshift deletions, and in-frame deletions are observed in cancers such as endometrial cancer, intestinal cancer, and skin cancer.
ABI1 is altered in 0.08% of all cancers with lung adenocarcinoma, acute myeloid leukemia, bladder urothelial carcinoma, breast invasive ductal carcinoma, and colon adenocarcinoma having the greatest prevalence of alterations .
The most common alteration in ABI1 is ABI1 K445N (0.26%) .
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