Location [1]
Protein [2]
Long-chain-fatty-acid--CoA ligase 6
Synonyms [1]

Acyl-CoA synthetase long-chain family member 6 (ACSL6) is a gene that encodes a catalytic protein that is involved in the production of acyl-CoA from fatty acids, ATP, and CoA. The protein functions in fatty acid metabolism in the brain. Fusions, missense mutations, nonsense mutations, silent mutations, and frameshift deletions and insertions are observed in cancers such as endometrial cancer, intestinal cancer, and skin cancer.

ACSL6 is altered in 0.09% of all cancers with breast invasive ductal carcinoma, invasive breast carcinoma, lung adenocarcinoma, appendix adenocarcinoma, and colon adenocarcinoma having the greatest prevalence of alterations [3].

ACSL6 GENIE Cases - Top Diseases


1. Hart R and Prlic A. Universal Transcript Archive Repository. Version uta_20180821. San Francisco CA: Github;2015. https://github.com/biocommons/uta

2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.

3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

4. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.