A-kinase anchoring protein 9 (AKAP9) is a gene that encodes a protein that functions as a regulator of protein kinase A. Missense mutations, synonymous mutations, nonsense mutations, frameshift deletions, frameshift insertions, and inframe insertions are observed in cancers such as stomach cancer, skin cancer, and endometrial cancer.
AKAP9 is altered in 0.57% of all cancers with breast invasive ductal carcinoma, high grade ovarian serous adenocarcinoma, mixed lobular and ductal breast carcinoma, breast invasive lobular carcinoma, and bladder urothelial carcinoma having the greatest prevalence of alterations .
The most common alterations in AKAP9 are AKAP9 Amplification (1.74%), AKAP9-BRAF Fusion (0.07%), AKAP9 I3840T (0.73%), AKAP9 S1028N (0.12%), and AKAP9 A771T (0.28%) .
2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.
3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.