Biomarkers /

ALOX12B

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Overview

Location [1]
17p13.1
Protein [2]
Arachidonate 12-lipoxygenase, 12R-type
Synonyms [1]
12R-LOX, ARCI2

ALOX12B is altered in 1.34% of all cancers with colon adenocarcinoma, lung adenocarcinoma, prostate adenocarcinoma, breast invasive ductal carcinoma, and endometrial endometrioid adenocarcinoma having the greatest prevalence of alterations [3].

ALOX12B GENIE Cases - Top Diseases

The most common alterations in ALOX12B are ALOX12B Loss (0.30%), ALOX12B Amplification (0.08%), ALOX12B P531L (0.02%), ALOX12B V435I (0.01%), and ALOX12B I239V (0.04%) [3].

ALOX12B GENIE Cases - Top Alterations

References

1. Hart R and Prlic A. Universal Transcript Archive Repository. Version uta_20180821. San Francisco CA: Github;2015. https://github.com/biocommons/uta

2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.

3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

4. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.