APC membrane recruitment protein 1 (AMER1) is a gene that encodes a protein that upregulates transcriptional activation by the Wilms tumor protein. Missense mutations, nonsense mutations, silent mutations, frameshift deletions, and frameshift insertions are observed in cancers such as colon cancer, kidney cancer, and endometrial cancer.
AMER1 is altered in 2.76% of all cancers with colon adenocarcinoma, lung adenocarcinoma, prostate adenocarcinoma, cutaneous melanoma, and rectal adenocarcinoma having the greatest prevalence of alterations .
The most common alterations in AMER1 are AMER1 Mutation (2.04%), AMER1 Loss (0.35%), AMER1 Amplification (0.23%), AMER1 R353* (0.06%), and AMER1 R497* (0.06%) .
2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.
3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.