Location [1]
Protein [2]
DNA dC->dU-editing enzyme APOBEC-3A
Synonyms [1]
PHRBN, ARP3, bK150C2.1, A3A

Apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3A (APOBEC3A) is a gene that encodes a protein that belongs to the cytidine deaminase enzyme family. The protein functions in immune regulation by inhibiting the transmission of viral DNA. Missense, nonsense, and silent mutations are observed in cancers such as endometrial cancer, esophageal cancer, and thyroid cancer.

Significance of APOBEC3A in Diseases

Cancer +

Central Nervous System Neoplasm +

Cholangiocarcinoma +

Malignant Solid Tumor +


1. Hart R and Prlic A. Universal Transcript Archive Repository. Version uta_20180821. San Francisco CA: Github;2015. https://github.com/biocommons/uta

2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.

3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

4. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.