Location [1]
Protein [2]
DNA dC->dU-editing enzyme APOBEC-3B
Synonyms [1]
APOBEC1L, A3B, ARP4, PHRBNL, bK150C2.2, ARCD3, DJ742C19.2

Apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3B (APOBEC3B) is a gene that encodes a protein that belongs to the cytidine deaminase enzyme family. The protein functions in RNA editing as well as the regulation of cell growth and cell cycle control. Missense mutations, nonsense mutations, silent mutations, and frameshift deletions are observed in cancers such as endometrial cancer, intestinal cancer, and stomach cancer.

Significance of APOBEC3B in Diseases

Breast Carcinoma +

Cancer +

Central Nervous System Neoplasm +

Cholangiocarcinoma +

Malignant Solid Tumor +


1. Hart R and Prlic A. Universal Transcript Archive Repository. Version uta_20180821. San Francisco CA: Github;2015. https://github.com/biocommons/uta

2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.

3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

4. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.