Associated Genetic Biomarkers
Associated Diseases


Location [1]
Protein [2]
DNA dC->dU-editing enzyme APOBEC-3G
Synonyms [1]
dJ494G10.1, ARP-9, ARCD, A3G, bK150C2.7, MDS019, CEM15, ARP9, CEM-15

APOBEC3G is altered in 1.03% of all cancers with conventional glioblastoma multiforme, cutaneous melanoma, adenocarcinoma of unknown primary, anaplastic oligodendroglioma, and basal cell carcinoma having the greatest prevalence of alterations [3].

APOBEC3G GENIE Cases - Top Diseases

The most common alterations in APOBEC3G are APOBEC3G Mutation (0.96%), APOBEC3G A109S (0.09%), APOBEC3G D128N (0.07%), APOBEC3G D317N (0.07%), and APOBEC3G D370A (0.09%) [3].

APOBEC3G GENIE Cases - Top Alterations

Significance of APOBEC3G in Diseases

Malignant Solid Tumor +

Cancer +

Central Nervous System Neoplasm +

Cholangiocarcinoma +


1. Hart R and Prlic A. Universal Transcript Archive Repository. Version uta_20180821. San Francisco CA: Github;2015.

2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.

3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

4. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.