Associated Genetic Biomarkers
Associated Diseases

Overview

Location [1]
22q13.1
Protein [2]
DNA dC->dU-editing enzyme APOBEC-3G
Synonyms [1]
MDS019, CEM-15, ARP9, A3G, ARCD, dJ494G10.1, CEM15, ARP-9, bK150C2.7

APOBEC3G is altered in 2.73% of all cancers with colorectal adenocarcinoma, leukemia, and malignant glioma having the greatest prevalence of alterations [3].

APOBEC3G GENIE Cases - Top Diseases

The most common alterations in APOBEC3G are APOBEC3G Mutation (0.02%), APOBEC3G F164Y (0.00%), APOBEC3G I266M (0.00%), APOBEC3G M295L (0.00%), and APOBEC3G N302Tfs*4 (0.00%) [3].

APOBEC3G GENIE Cases - Top Alterations

Significance of APOBEC3G in Diseases

Cholangiocarcinoma +

Malignant Solid Tumor +

References

1. Hart R and Prlic A. Universal Transcript Archive Repository. Version uta_20170629. San Francisco CA: Github;2015. https://github.com/biocommons/uta

2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.

3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 4. This dataset does not represent the totality of the genetic landscape; see paper for more information.

4. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.