Overview

Location [1]
Xq12
Pathway
Hormone signaling
Synonyms [1]
TFM, AIS, HUMARA, SBMA, KD, SMAX1, NR3C4, AR8, HYSP1, DHTR

AR (androgen receptor) is a gene that encodes the androgen receptor protein. AR plays a role in the pathogenesis of prostate cancer (PMID: 21989426PMID: 18507821). AR amplification and AR mutations occur in castration-resistant prostate cancer (PMID: 22245783). AR expression has also been observed in invasive breast cancers (PMID: 21552212; PMID: 18507821). 

 

Biomarker-Directed Therapies

Clinical Trials

Significance of AR in Diseases

Breast Carcinoma +

Malignant Salivary Gland Neoplasm +

Prostate Adenocarcinoma +

Prostate Carcinoma +

Salivary Gland Carcinoma +

Adenocarcinoma Of Unknown Primary +

Bladder Carcinoma +

Clear Cell Renal Cell Carcinoma +

Fallopian Tube Carcinoma +

Invasive Breast Carcinoma +

Malignant Solid Tumor +

Ovarian Carcinoma +

Pancreatic Carcinoma +

Primary Peritoneal Carcinoma +

Renal Pelvis And Ureter Carcinoma +

Salivary Duct Carcinoma +

Urethral Carcinoma +

Urothelial Carcinoma +

References

1. Hart R and Prlic A. Universal Transcript Archive Repository. Version uta_20180821. San Francisco CA: Github;2015. https://github.com/biocommons/uta

2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.

3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

4. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.