Biomarkers /
AR
Overview
AR (androgen receptor) is a gene that encodes the androgen receptor protein. AR plays a role in the pathogenesis of prostate cancer (PMID: 21989426; PMID: 18507821). AR amplification and AR mutations occur in castration-resistant prostate cancer (PMID: 22245783). AR expression has also been observed in invasive breast cancers (PMID: 21552212; PMID: 18507821).
Biomarker-Directed Therapies
Clinical Trials
Significance of AR in Diseases
References
1. Hart R and Prlic A. Universal Transcript Archive Repository. Version uta_20180821. San Francisco CA: Github;2015. https://github.com/biocommons/uta
2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.
3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.
4. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.