Overview

Location [1]
Xq12
Pathway
Hormone signaling
Protein [2]
Androgen receptor
Synonyms [1]
KD, HUMARA, DHTR, SMAX1, AR8, SBMA, TFM, NR3C4, HYSP1, AIS

AR (androgen receptor) is a gene that encodes the androgen receptor protein. AR plays a role in the pathogenesis of prostate cancer (PMID: 21989426PMID: 18507821). AR amplification and AR mutations occur in castration-resistant prostate cancer (PMID: 22245783). AR expression has also been observed in invasive breast cancers (PMID: 21552212; PMID: 18507821). 

 

AR is altered in 3.28% of all cancers with prostate cancer, non-small cell lung carcinoma, colorectal adenocarcinoma, uterine corpus neoplasm, and breast carcinoma having the greatest prevalence of alterations [3].

AR GENIE Cases - Top Diseases

The most common alterations in AR are AR Mutation (2.53%), AR Amplification (0.68%), AR Loss (0.11%), AR G473dup (0.09%), and AR Q58L (0.07%) [3].

AR GENIE Cases - Top Alterations

References

1. Hart R and Prlic A. Universal Transcript Archive Repository. Version uta_20170629. San Francisco CA: Github;2015. https://github.com/biocommons/uta

2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.

3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 4. This dataset does not represent the totality of the genetic landscape; see paper for more information.

4. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.