Associated Genetic Biomarkers
AR (androgen receptor) is a gene that encodes the androgen receptor protein. AR plays a role in the pathogenesis of prostate cancer (PMID: 21989426; PMID: 18507821). AR amplification and AR mutations occur in castration-resistant prostate cancer (PMID: 22245783). AR expression has also been observed in invasive breast cancers (PMID: 21552212; PMID: 18507821).
AR is altered in 3.28% of all cancers with prostate cancer, non-small cell lung carcinoma, colorectal adenocarcinoma, uterine corpus neoplasm, and breast carcinoma having the greatest prevalence of alterations .
The most common alterations in AR are AR Mutation (2.53%), AR Amplification (0.68%), AR Loss (0.11%), AR G473dup (0.09%), and AR Q58L (0.07%) .
2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.
3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 4. This dataset does not represent the totality of the genetic landscape; see paper for more information.