Rho GTPase activating protein 26 (ARHGAP26; also known as GRAF) is a gene that encodes a protein that functions in binding to focal adhesion kinases. The protein also regulates the activity of GTP binding proteins RhoA and Cdc42. Fusions, missense, nonsense, and silent mutations are observed in cancers such as endometrial cancer, intestinal cancer, and stomach cancer.
ARHGAP26 is altered in 0.07% of all cancers with lung adenocarcinoma, colon adenocarcinoma, melanoma, pancreatic adenocarcinoma, and acute undifferentiated leukemia having the greatest prevalence of alterations .
The most common alterations in ARHGAP26 are ARHGAP26 Mutation (1.44%), ARHGAP26 A682V (0.08%), ARHGAP26 E339K (2.04%), ARHGAP26 G281E (0.08%), and ARHGAP26 G366S (0.08%) .
2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.
3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.